Tfw no trip 😢
This is how I stopped my SSRIs and microdosed instead :3
It's illegal because it works
I've been approved for ketamine therapy, hopefully that does something for me
Any kind of SSRI medication does. Whatever serotonin shenanigans the meds do have a negative impact on certain recreational drugs like mushrooms and MDMA.
I'm pretty sure this is part of what can make them effective for quitting smoking or drinking.
I've heard before that SSRIs will dampen most psychedelic effects
Idk I had an eighth of shrooms with my partner last night. They DEFINITELY worked for her, I just felt a little warm and cozy for an hour or so then was pretty much back to normal
SSRIs will blunt the effects of classical psychedelics, you'll still feel something but it'll be as if you'd taken a much smaller dose.
It’s been a dogs age since I foxed around with psychedelics but I seem to remember this being true of SSRIs in general.
Hopefully you aren’t out too much money.
oh shit.. i think i owe a friend back in college some money then.. he gave me shrooms like 3 times and i kept telling him they were all bs coz nothin happened.. but i was on welbutrin and effexor at the time.. i didn't know they cancelled out the effects
My partner bought them and tripped too, she was perfectly happy to do it. I felt bad about her spending the money on me, she felt bad that I couldn't share the experience
While SSRI's just completely blunt the effect of psychadelics (seratonin agonists), in the case of MDMA it's actually more dangerous than that because taking it while on SSRI's could cause seratonin syndrome
I wouldn't be too worried about it. DXM with an SSRI on the other hand is a great way to get seratonin syndrome
Are you saying MDMA + SSRI is nothing to worry about? Is this claimed in the study you linked?
Another study: https://pubmed.ncbi.nlm.nih.gov/24006318/
MDMA, in combination with the widely-prescribed SSRI antidepressant class, can lead to rapid, synergistic rise of serotonin (5-HT) concentration in the central nervous system, leading to the acute medical emergency known as serotonin syndrome.
The study I linked has data from poison control and hospitals, and breaks down calls made for seratonin sydnrome.
What you linked isn't a study, but a review. No new information is brought up, it talks pharmacology that makes sense, but has no actual evidence (such as a case of a person getting seratonin syndrome from the mixture), it just makes a hypothesis that frequent prescriptions of SSRIs along with SSRI users being more likely to be MDMA users as well, which could potentially be responsible for this because it pharmacologically gives some sort of explaination. This is also about primarily about adolescents, who are much more susceptible to seratonin poisoning.
Look up the DOI number on pubmed articles before sharing them, it's irresponsible not to
The study I linked has data from poison control and hospitals, and breaks down calls made for seratonin sydnrome.
This one? https://doi.org/10.1007/s00213-021-05876-x
That is still just an abstract, and it's on a different website so I'm not really sure
I will add this by "look up the DOI" I meant "look up the DOI on sci-hub". It will give you the full text of anything on PubMed. Both of these articles we're discussing are not webpages, but 7 page long journals. There's a lot more information than is given on the webpage. If you read something in either of those and disagree with me, I'm more than open to discussing it and changing my comments
But from me reading all the full texts I have, I still haven't found any solid evidence that MDMA and SSRIs will kill you (more than just these two). Will weaken the effects sure, but so far all I can find on the MDMA+SSRI interaction is questions about the pharmacology of it, which makes sense but really doesn't sell me.
So the pubmed page you linked to, titled "Serotonin toxicity of serotonergic psychedelics" looks like a review as well. I got the full paper on sci-hub and it didn't appear to be what you were describing, so I asked for confirmation of the DOI.
What I meant by
This one? https://doi.org/10.1007/s00213-021-05876-x
is "is this the correct DOI?", not "is this page on doi.org the full paper you're referencing?"
To be blunt, it looks like you've mixed up your links, and the one you've been talking about is not the one you linked. Can I please have the DOI or any link about the study you've been talking about?
Doesn't molly and ssri lead to like potentially fatal interactions?
Yes, it does. Molly on its own is dangerous, and combined with an SSRI can be fatal. I don't know why people are lumping Molly and psychedelics into the same category. The classical psychedelics (psylocibin, LSD, mescaline) are not neurotoxic.
RIP trips :( mine definitely wasn't as hard as usual last time because I'm on Zoloft now.
It definitely helps with depression, not as effective as it was the first few weeks of it but it still makes quite the difference. Seasonal depression is starting to hit me pretty hard, so I might need to get a dose increase
No-fun Zoloft gang! It's the best antidepressant of the dozen I've tried but maaaan it sure put a damper on my fun drugs.
