As a reminder, be sure to properly give content warnings and put sensitive subjects behind proper spoiler tags. It's for the mental health of not just your comrades, but yourself as well.
Here is a screenshot of where to find the spoiler button.
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I don't know anything about using them for monotherapy but estradiol pills are usually taken sublingually and don't do a liver pass.
Monotherapy would probably take a lot of pill dissolving lol.