Another likely part of this is that powerusers (to my knowledge) don't really get bogged down with too many replies. The only way you can be a poweruser (in the sense that your posts and comments get tons of upvotes, not in the sense that you're just online all the time) is to game the system by carefully choosing posting times, getting in early on threads, meming, copying shit that was popular the last time that thread popped up, and (in many cases) vote manipulation. That's a lot of work, and none of it involves being engaged enough with replies to make an issue out of someone misgendering you.
Another likely part of this is that powerusers (to my knowledge) don't really get bogged down with too many replies. The only way you can be a poweruser (in the sense that your posts and comments get tons of upvotes, not in the sense that you're just online all the time) is to game the system by carefully choosing posting times, getting in early on threads, meming, copying shit that was popular the last time that thread popped up, and (in many cases) vote manipulation. That's a lot of work, and none of it involves being engaged enough with replies to make an issue out of someone misgendering you.