Children of Time is a 2015 science fiction novel by Adrian Tchaikovsky.
In the distant future, humanity seeks to create new habitats for itself on distant planets, terraforming them and seeding them with life. Dr. Avrana Kern is heading one such project, orbiting the tentatively named "Kern's World", where the plan is to release monkeys infected with a nanovirus that will accelerate their evolution. Through an act of sabotage from an anti-technology group that has also destroyed much of Earth, the monkeys are never released, and the virus instead infects a species of spider, Portia labiata. The book follows the evolution of the spiders and their eventual civilisation, as well as a remnant of humanity that fled to Kern's World hoping to find paradise.
also children of ruin and children of memory, the sequels, are really good
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For me, I knew I was ace before realizing I was trans, so can't really comment on sexual attraction. Spiro+E really nerfed my libido within a couple weeks, but horny has returned occasionally (to my annoyance), but that might sometimes be related to missing spiro doses (not sure how the pharmacokinetics work for that - sometimes it seems delayed from the missed doses by a couple days). OTOH, I've probably started appreciating other people's bodies more, but that's probably just that I subconsciously learned to avoid paying attention to human bodies and now I have less reason to do that.
Hope you are able to figure something out, whether learning how to work with your current sexuality or get back what you had before.