her,,, expolde

Show

Join our puplic Matrix server! https://matrix.to/#/#tracha:chapo.chat

As a reminder, be sure to properly give content warnings and put sensitive subjects behind proper spoiler tags. It's for the mental health of not just your comrades, but yourself as well.

Here is a screenshot of where to find the spoiler button.

Show

  • ashinadash [she/her]
    ·
    2 months ago

    Sorry my gender has been really boring the past few weeks, everyone lea-sad

    Uh cutting my cyproterone acetate dose down to 12.5mg has been rad at least, did that a couple weeks ago now...

      • ashinadash [she/her]
        ·
        2 months ago

        Awwwwwh no toriel-blush

        Idk, sometimes I worry about spamming the mega with too many gender-unrelated things. Like Wayhaven you can play as an enby so it counts, but I have not made a Genderpost really since I got skirtpilled...

        • MusicOwl [comrade/them, sie/hir]M
          ·
          2 months ago

          I contend that every post is a gender post, cis or trans, and we must vastly increase the number of transgender posts to down the cis. theory-gary

    • imogen_underscore [it/its, she/her]
      ·
      2 months ago

      cypro is busted, I cut to 12.5 every 2 days a while ago and still have next to zero T. would honestly like a little more lol, maybe I should cut it even further.

      • ashinadash [she/her]
        ·
        2 months ago

        I would like to do that too, I worry that cypro every other day would mess with my mood though...

        Under socialism cypro tabs will be 25mg and split four ways easy into 6.25mg or whatever.

        • imogen_underscore [it/its, she/her]
          ·
          2 months ago

          I'm fairly sure because of its long ass half life 12.5 every other day is more or less equivalent to 6.25 daily! I haven't noticed any mood or energy issues since switching:)

              • ashinadash [she/her]
                ·
                2 months ago

                and at doses of 50 to 300 mg/day as an antiandrogen.

                Uh I think that entire range is irl crimes madeline-shock

                the more as some of the side effects may be related to the progestational overdosage rather than to the administered antiandrogenic activity. […] Adverse reactions like tiredness, lassitude, and increase in body weight are possibly due to the enormous overdose of progestational activity in the formula

                Well that fuckin makes sense, and these studies are from the 1970s, ffs. Western medicine is a joke. What interested me here though

                T decreased from ~431 ng/dL at baseline to ~149 ng/dL with CPA (–65%) for the 10 and 20 mg/day doses combined.

                Seeing figures like this make me go Oh, well that's not like upwards of 90%! But as stated in the article E, even at like 4mg would offer a pretty good amount of suppression too though, these dorks are cypro only:

                Fung and colleagues showed that the combination of either 25 or 50 mg/day CPA with a moderate dosage of oral estradiol (~3.5 mg/day) or transdermal estradiol (~3.5 mg/day gel or ~100 μg/day patch) resulted in equivalent and complete suppression of gonadal testosterone production (~95% suppression of testosterone levels) in transfeminine people (Fung, Hellstern-Layefsky, & Lega, 2017).

                So CPA's not 100% effective on its own under 50mg, but more than like 10mg is overkill with estrogen:

                Accordingly, Meyer et al. (2020) assessed a dosage of CPA in combination with estradiol in 155 transfeminine people and found no difference in testosterone levels with 10, 25, or 50 mg/day CPA; testosterone levels were strongly suppressed with all three doses (to about 15–20 ng/dL on average, or into the lower end of the normal female range). The estradiol forms and doses used in this study were oral estradiol valerate (median 6 mg/day, range 3–10 mg/day), transdermal estradiol gel (median 2.25 mg/day, range 1.5–6 mg/day), and transdermal estradiol patches (100 μg/day in all cases). Estradiol levels were about 100 pg/mL on average, with an interquartile range (i.e., difference between 75th and 25th percentiles) of about 100 pg/mL. This study demonstrates that, provided estradiol levels are adequate, no more than 10 mg/day CPA is needed to fully suppress testosterone levels in transfeminine people.

                I think I'll wait to do 6mg though, I dunno:

                Even doses of CPA lower than 5 mg/day (e.g., 2 mg/day) may be usefully effective for testosterone suppression if combined with sufficient levels of estradiol, although this has not been studied and remains to be validated. But there is certainly precedent for the notion when looking at studies with other progestogens.

                I don't see a lot of support for lower than 10mg, Idk. I do wish this shit came in 10 or 20mg tabs instead of fucking 50.

                • imogen_underscore [it/its, she/her]
                  ·
                  2 months ago

                  yeah it's a pain. I guess it can vary from person to person, my choice to go to 6 was also informed by anecdotal accounts on bsky of its effectiveness at that dose, and for me my T is perfectly acceptable at 6.25 along with my estrogel. I didn't really experience the increased energy and stuff that some folks report with the lower dose, but relying on less of a drug is just nice. also yeah it's off the wall that we used to get prescribed more than 50mg, that's gotta do some damage.

                  • ashinadash [she/her]
                    ·
                    2 months ago

                    It worries me now that I took 50mg for like a few years, guess it could have been worse but dang... relying on less of a drug is cool, I'll see Idk. I'm not really smart enough for all this chemist shit sadly, much as I would adore becoming a trans Doctor Without Borders or smth.

                    • imogen_underscore [it/its, she/her]
                      ·
                      2 months ago

                      what's nice is that i was able to stockpile it for a while and then one of my gfs was able to switch to it from spiro without needing a script, I get enough from the pharmacy for both of us hehe. and I wouldn't worry, 50mg may be too much for hrt but it shouldn't have done any harm from what I know if you were presumably on estrogen at the same time.

                      • ashinadash [she/her]
                        ·
                        2 months ago

                        waow-based CPA stockpile...

                        Yeah I was on 4mg lupin-estradiol the whole time, so that's good...

          • naom3 [she/her]
            ·
            2 months ago

            Yeah my doctor told me I could take the whole 50mg pill every 4 days if I wanted to

    • rtstragedy [fae/faer, she/her]
      ·
      2 months ago

      damn i keep forgetting to talk to my doctor about that i am still on spiro, were you on spiro before? is cypro way better?

      • imogen_underscore [it/its, she/her]
        ·
        2 months ago

        cypro is a significantly more effective T blocker with less side effects and will be preferable in the majority of cases. it's also a progestogen iirc which is cool?

        • BountifulEggnog [she/her]
          ·
          2 months ago

          Why do they prescribe spiro then? I feel like I see a lot of people starting on spiro.

          • ashinadash [she/her]
            ·
            2 months ago

            CPA is fuckin illegal or some shit in the burger reich for some goddamn reason. Fucking FDA bullshit probably.

              • ashinadash [she/her]
                ·
                2 months ago

                Yeah I'm not doing crimes by eating it, lol. It's legal like everywhere else in the world, just not in the joke burger failstate :3

                • rtstragedy [fae/faer, she/her]
                  ·
                  2 months ago

                  so maybe I should talk to doctor then, but then i have to make a phone call to the very nice people at my clinic (they are very sweet) and see my very nice doctor (i am very lucky, my last doctor quit and there's real problem with docs in my "city"

                  Joke Burger Failstate

                  beautiful word rhythm, as always. i prefer to come up with phrases for people and things when i'm talking about them that describe my connections to them, this is a good example lol

                  • ashinadash [she/her]
                    ·
                    2 months ago

                    Phone calls are shit but that's what I did, was talked to my endo and got switched, it's rad.

                    :3 Yeah it slaps, I'm big into the "burgerreich" term originating from here as well

            • MusicOwl [comrade/them, sie/hir]M
              ·
              2 months ago

              The purported reason it is illegal in amerikkka is that cpa has a very rare probability of creating non malignant brain tumours.

          • imogen_underscore [it/its, she/her]
            ·
            2 months ago

            cpa isn't FDA approved I think. I'm in EU where it's much more common than spiro and it is just better by the current literature. online english spaces tend to be US centric so you see a lot of spiro talk.

          • naom3 [she/her]
            ·
            2 months ago

            The company that makes it literally cannot be bothered to apply to get it approved by the FDA so doctors aren’t allowed to prescribe it

      • ashinadash [she/her]
        ·
        2 months ago

        Yes I was on spiro :3 I peed a lot and sort of desired the "depressive" effects of cypro since I have extremely poor emotional regulation, but 50mg is too much beyond a temp dose usually. Even on 12.5mg my T levels are almost nothing, which fucks. It's good at what it does, but whatever antiandrogen method works best is what's best for you. If your levels come out well and the side effects of spiro (mostly just pee Idk) are fine by you, dw abt it tbh.

        • rtstragedy [fae/faer, she/her]
          ·
          2 months ago

          but 50mg is too much beyond a temp dose usually

          you mean on cypro, right? i'm on 300mg spiro...

          Even on 12.5mg my T levels are almost nothing, which fucks

          ok yeah i follow now

          If your levels come out well and the side effects of spiro (mostly just pee Idk) are fine by you, dw abt it tbh.

          yeah i'm planning to get bottom surgery (or at least I think I am? oh man that's a whole thing right now that I'm trying to process in small bursts) so I was just gonna go off anti-andros after that

          • ashinadash [she/her]
            ·
            2 months ago

            Yeah I mean cypro, which comes in 50mg tabs but should AT LEAST be divvied into 25mg halves, and I've seen as low as like 6mg. Spiro, anything from 150mg to like, 400mg? is normal.

            The bottom surgery conundrum bocchi-head-shake going off antiandros is pretty based, good for your kidneys and/or liver.

            • rtstragedy [fae/faer, she/her]
              ·
              2 months ago

              yeah, this is why i need to Perfectly Understand My Gender As Soon As Possible, so that I know I'm making the right decision.

              • ashinadash [she/her]
                ·
                2 months ago

                kel-what But surely there's no pressure, and you can take your time deciding how you feel about it, right?

                • rtstragedy [fae/faer, she/her]
                  ·
                  2 months ago

                  yeah i decided on the 1-3 year option in a nearby city (that i used to live in lol, so at least i know it well) instead of flying across the country for the less than a year option, which came with a bunch of caveats like i have to get electrolysis done etc.

                  ...this post is an opsec failure

                  • ashinadash [she/her]
                    ·
                    2 months ago

                    I couldn't dox you fwiw ✨ also caveats suck, death to the medicalisation of trans people under this system.

                    • rtstragedy [fae/faer, she/her]
                      ·
                      2 months ago

                      Oh but I guess at least I dont have to pay anything! That's an improvement over years ago when I started transition

                    • rtstragedy [fae/faer, she/her]
                      ·
                      2 months ago

                      Thats a relief that at least (although I'm not concerned about anyone posting in bear site in this regard, come visit, but it IS a public forum), but it will be nice to be nearby and not have to fly for the appointments and surgery, even if it does take longer and I have to get hair removal.

        • MusicOwl [comrade/them, sie/hir]M
          ·
          2 months ago

          Woof I had to stop spiro because the brain fog was so bad that it was hazardous for me to drive. So glad I’m just on monotherapy now.

      • naom3 [she/her]
        ·
        2 months ago

        I was on spiro briefly before switching to cypro. I had the excessive peeing, but mainly it just made me really dizzy. Cypro is way better

    • naom3 [she/her]
      ·
      2 months ago

      I just switched down from 12.5 mg daily to 6.25 mg daily (12.5 every other day). I haven’t got my levels checked yet, and it’s probably fine, but I’m still worried it’s gonna make my T levels go up. Hopefully being on a lower dose makes the prog less depressive